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LABORATORY TEST DIRECTORY

EGFR Mutation Detection by Pyrosequencing

CPT Code(s): 88381; 81235
Specimen Required: Patient Preparation:For a general FNA collection and smear preparation refer to RDL's Laboratory Test Directory: Cytology, Fine Needle Aspiration Collection at http://www.reliancediagnosticslab.com/guides/ug/tests/RDL014.jsp
Collect:Tumor tissue.
Specimen Preparation:Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue block or 5 unstained 5-micron slides. (Min: 3 slides) Tissue block will be returned after testing. A Fine Needle Aspirate (FNA) smear may also be submitted. Prepare FNA smear with Diff-Quik or equivalent stain by standard methods (air-dried slides are preferred). Number of slides needed is dependent on the tumor cellularity of the smear. (Min: 1 slide). Slide(s) will be destroyed during testing process and will not be returned to client.Transport block and/or slide(s) in a tissue transport kit (RDL supply #47808) available online through eSupply using RDL Connectâ„¢ or contact RDL Client Services at (888) 431-7474.
Storage/Transport Temperature:
Stability:Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
New York DOH Approval Status: This test is New York DOH approved.
Aliases:
  • EGFR-TKI
  • EGFR-tyrosine kinase inhibitor
  • Epidermal growth factor receptor
  • ERBB1
  • Erlotinib Responsiveness in NSCLC
  • Gefitinib Responsiveness in NSCLC
  • IRESSA Responsiveness in NSCLC
  • Non-small Cell Lung Cancer (NSCLC) Therapeutic Panel
  • Tarceva Responsiveness in NSCLC