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KRAS Mutation Detection with Reflex to BRAF Codon 600 Mutation Detection

CPT Code(s): 88381; 81275; 81276; If reflexed, add 81210
Specimen Required: Patient Preparation:
Collect:Tumor tissue.
Specimen Preparation:Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect paraffin block from excessive heat. Transport tissue block or 5 unstained 5-micron slides. (Min: 3 slides). Transport block and/or slide(s) in a tissue transport kit (RDL supply #47808) available online through eSupply using RDL Connectâ„¢ or contact RDL Client Services at (888) 431-7474.
Storage/Transport Temperature:Room temperature or refrigerated.  Ship in cooled container during summer months.
Stability:bient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
New York DOH Approval Status: This test is New York DOH approved.
  • Anti-EGFR therapy eligibilityanti-EGFR therapy resistance testingBRAF codon 600Cetuximab (Erbitux)KRAS codons 12, 13, 61Panitumumab (Vectibix)RAS