PDGFRB FISH for Gleevec Eligibility in Myelodysplastic Syndrome/Myeloproliferative Disease (MDS/MPD)
| CPT Code(s): | 88271; 88275; 88291 |
| Specimen Required: | Patient Preparation:PDGFRB FISH for Gleevec Eligibility in MDS/MPD is approved by the FDA as a Humanitarian Device for FISH testing of the PDGFRB gene to determine mutational status in patients with MDS/MPD. Testing must be ordered using the following instructions:
1. The ordering physician must register with the Internal Review Board (IRB) for PDGFRB FISH for Gleevec Eligibility in MDS/MPD testing. Go to http://www.reliancediagnosticslab.com/PDGFRB to obtain IRB registration online.
2. The test should be ordered using the RDL test requisition form or via RDL's web-based ordering interface (available only to existing RDL clients). The full name of the ordering physician must be included on the RDL form to ensure timely testing of the specimen. Specimens submitted with incomplete information may delay specimen testing.
3. To send a specimen to RDL, contact your local hospital/reference lab to determine if they are an RDL client and can send the specimen. If they cannot send the specimens to RDL, contact RDL Client Services at (888) 431-7474 to be directed to an alternative ordering mechanism.
4. Information about the PDGFRB FISH for Gleevec Eligibility in MDS/MPD test and IRB registration may be accessed at www.reliancediagnosticslab.com/PDGFRB.
5. RDL will receive specimens via usual shipping routes, from designated clients. When the specimen arrives, with an accompanying requisition, the physician's full name will be logged in, if present. If the ordering physician's full name is not present, the specimen is placed on EXCEPT by the Integrated Oncology and Genetics (IOG) services group. The IOG services group will then attempt to locate the physician for confirmation of IRB registration. Upon confirmation of physician registration, the IOG services group will notify the Cytogenetics clinical laboratory, and testing will proceed. Collect:Non-diluted bone marrow aspirate collected in a heparinized syringe. Also acceptable: Green (sodium heparin). Specimen Preparation:Transfer 3 mL bone marrow to a green (sodium heparin) tube. (Min: 1 mL) Storage/Transport Temperature:Room temperature. Stability:Specimen must be received and testing initiated within: Ambient: 3 days; Refrigerated: Unacceptable; Frozen: Unacceptable |
| New York DOH Approval Status: | This test is New York DOH approved. |
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